{
  "cases": [
    {
      "description_en": "PRJEB70964 links archived counts to reported constructs and two source-reported apparent affinities.",
      "description_zh": "PRJEB70964将归档计数与文献构建体及2个原文表观亲和力值关联。",
      "label_en": "RNA selection history and reported molecular evidence",
      "label_zh": "RNA筛选历史与文献分子证据",
      "url": "/web/cases/selection-evidence"
    },
    {
      "description_en": "3 primary endpoints; 3 imported observations. This checks reported assay context, not a sequencing-round chain.",
      "description_zh": "复核3个原文指标条目、3个导入观测，保留原文测量背景；不将其表述为测序轮次链。",
      "label_en": "Aptamer-Based Molecular Recognition of Lysergamine, Metergoline and Small Ergot Alkaloids",
      "label_zh": "原文对应复核：小分子结合",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3546743/"
    },
    {
      "description_en": "4 primary endpoints; 6 imported observations. This checks reported assay context, not a sequencing-round chain.",
      "description_zh": "复核4个原文指标条目、6个导入观测，保留原文测量背景；不将其表述为测序轮次链。",
      "label_en": "Screening and Improvement of an Anti-VEGF DNA Aptamer",
      "label_zh": "原文对应复核：抗VEGF结合",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6256979/"
    }
  ],
  "cohort_note_en": "Projects, target groups, archive objects and molecules are different counting units. The cohorts overlap and must not be added.",
  "cohort_note_zh": "项目、靶标组、归档对象和分子是不同计数单位；队列之间有重叠，不能相加。",
  "cohorts": [
    {
      "access_en": "Target and retained-sequence queries. Twenty groups reach the 10,000-record cap.",
      "access_zh": "可查询靶标和保留序列；20组达到每组10,000条的保留上限。",
      "id": "retained_aptamer_selection",
      "label_en": "Queryable aptamer-selection subset",
      "label_zh": "可查询的适配体筛选子集",
      "scale_en": "208,754 candidates; 25 source-target groups; 125 rounds; 996,316 sequence–round observations.",
      "scale_zh": "208,754条候选记录；25个来源靶标组；125条轮次记录；996,316条序列—轮次观测。",
      "url": "/web/targets"
    },
    {
      "access_en": "Source inventory is documented here; complete archive count exports are not published.",
      "access_zh": "可下载来源统计清单；完整归档计数尚未公开。",
      "id": "processed_archive",
      "label_en": "Processed aptamer-selection archive",
      "label_zh": "已处理的适配体筛选归档",
      "scale_en": "19 project groups; 390 archive objects; 3,113,731,979 read records, including known cross-deposit aliases.",
      "scale_zh": "19个项目组；390个归档对象；3,113,731,979条读段记录，包含已知跨归档别名。",
      "url": ""
    },
    {
      "access_en": "Interactive case, per-construct API and numerical downloads.",
      "access_zh": "可浏览案例、逐构建体API及数值下载。",
      "id": "linked_case",
      "label_en": "Public RNA selection case",
      "label_zh": "公开RNA筛选案例",
      "scale_en": "13 reported constructs; 27 archive objects; 351 observations; two apparent-affinity values.",
      "scale_zh": "13个文献构建体；27个归档对象；351个观测；2个表观亲和力值。",
      "url": "/web/cases/selection-evidence"
    },
    {
      "access_en": "A separate source-purpose layer, not the aptamer-selection total.",
      "access_zh": "独立保留来源用途，不作为适配体筛选总数。",
      "id": "auxiliary_recognition",
      "label_en": "Auxiliary recognition catalogue",
      "label_zh": "辅助核酸识别目录",
      "scale_en": "30,439,227 candidates across all purposes; 29,820,473 assigned TF–DNA recognition.",
      "scale_zh": "各类来源共30,439,227条候选记录，其中29,820,473条被归类为TF–DNA识别。",
      "url": "/web/release"
    },
    {
      "access_en": "File-scoped queries and Parquet downloads.",
      "access_zh": "可逐文件查询并下载Parquet计数。",
      "id": "native_counts",
      "label_en": "Public source-file count exports",
      "label_zh": "公开来源文件计数",
      "scale_en": "125 files; 436,660,114 reads from five primarily TF–DNA collections.",
      "scale_zh": "五个主要为TF–DNA结合的来源集合，共125个文件、436,660,114条读段。",
      "url": "/web/source-counts"
    }
  ],
  "core_census_manifest_sha256": "a3e1e246fff4aca3b275259752c78f841d90e31f7a1f8e42c744fde59929f2d6",
  "coverage_note_en": "Coverage is recomputed from explicit identifiers in the frozen literature cohort. Source-catalogue links connect 810 assays, 671 constructs and 227 campaigns; those catalogue records do not contain high-throughput round counts.",
  "coverage_note_zh": "覆盖率由冻结文献队列的明确标识重新计算。来源目录关联包含810个测量、671个构建体和227个筛选活动；这些目录记录不包含高通量轮次计数。",
  "date": "2026-10-16",
  "format": "panapta-coverage-quality-summary/v1",
  "headline_metrics": [
    {
      "id": "retained_candidates",
      "label_en": "Retained aptamer-selection candidates",
      "label_zh": "保留的适配体筛选候选记录",
      "scope_en": "25 source-target groups · 18 archive projects",
      "scope_zh": "25个来源靶标组 · 18个归档项目",
      "value": 208754
    },
    {
      "id": "reported_constructs",
      "label_en": "Source-described constructs",
      "label_zh": "来源描述的构建体",
      "scope_en": "A separate literature-derived cohort",
      "scope_zh": "独立的文献构建体队列",
      "value": 2993
    },
    {
      "id": "measurement_records",
      "label_en": "Measurement source records",
      "label_zh": "测量来源记录",
      "scope_en": "Typed endpoints and source-specific contexts",
      "scope_zh": "保留指标类型与原始测量背景",
      "value": 1707
    }
  ],
  "interpretation": [
    {
      "en": "The 677-entry shared name registry contains 665 supported or qualified source associations; 12 entries still lack positive target-specific support. It is not a 677-target aptamer-selection release.",
      "zh": "677条共享名称登记中，665条有正向或限定来源关联，12条仍缺正向靶标证据；不能据此称为677个已发布适配体筛选靶标。"
    },
    {
      "en": "Missing chemistry has source-field reasons; an empty field is not evidence of an unmodified construct or whole-article nonreporting.",
      "zh": "化学信息缺失按来源字段原因区分；空字段不能证明构建体未修饰，也不能证明整篇文章未报告。"
    }
  ],
  "introduction_en": "Browse the published scopes, explicit molecular relationships and source-quality checks behind PanApta.",
  "introduction_zh": "查看PanApta各类数据的实际范围、明确的分子关联及来源质量检查。",
  "link_metrics": [
    {
      "colour": "#1f78b4",
      "count": 694,
      "denominator": 2993,
      "id": "assay_constructs",
      "label_en": "Constructs with explicit assay links",
      "label_zh": "明确关联测量的构建体",
      "note_en": "844 measurement records refer explicitly to these 694 constructs.",
      "note_zh": "844条测量记录通过明确构建体标识关联到这694个构建体。"
    },
    {
      "colour": "#33a02c",
      "count": 295,
      "denominator": 2993,
      "id": "chemistry",
      "label_en": "Constructs with modification descriptions",
      "label_zh": "有修饰描述的构建体",
      "note_en": "A description does not by itself resolve complete chemical identity.",
      "note_zh": "已有描述不自动等于完整化学身份已明确。"
    },
    {
      "colour": "#e31a1c",
      "count": 47,
      "denominator": 2993,
      "id": "joint",
      "label_en": "Constructs with both links and chemistry descriptions",
      "label_zh": "同时具有测量关联和修饰描述的构建体",
      "note_en": "The denominator is the same 2,993-construct cohort.",
      "note_zh": "分母同为2,993个构建体。"
    }
  ],
  "nucleotide_strings_included": false,
  "quality_checks": [
    {
      "action_en": "Source interpretation is evaluated separately.",
      "action_zh": "来源科学含义另行复核。",
      "label_en": "Numeric and foreign-key checks",
      "label_zh": "数值与外键检查",
      "result_en": "1,707 / 1,707 rows pass implemented checks.",
      "result_zh": "1,707条记录均通过已实现的检查。"
    },
    {
      "action_en": "20 AptamerBase and 22 UTexas observations; this checks imported source literals.",
      "action_zh": "AptamerBase 20个、UTexas 22个；检查对象为导入来源字段。",
      "label_en": "Imported-literal replay",
      "label_zh": "导入字面值复算",
      "result_en": "42 / 42 selected source observations agree numerically.",
      "result_zh": "抽取的42个来源观测数值均可复算。"
    },
    {
      "action_en": "One squared-concentration constant excluded from concentration Kd; four pH contexts flagged.",
      "action_zh": "1个浓度平方常数移出浓度Kd分布；4个pH背景标记为冲突。",
      "label_en": "Primary article correspondence",
      "label_zh": "原始文献对应复核",
      "result_en": "Two articles; seven endpoints; nine source observations.",
      "result_zh": "2篇原始文献、7个指标条目、9个来源观测。"
    },
    {
      "action_en": "Flags recomputed from explicit assay identifiers; numeric source values preserved.",
      "action_zh": "已按明确测量标识重算标记，保留原始数值。",
      "label_en": "Assayed-construct flags",
      "label_zh": "测量构建体标记",
      "result_en": "806 exported flags disagreed with actual assay foreign keys.",
      "result_zh": "806个导出标记与实际测量外键不一致。"
    }
  ],
  "quality_manifest_sha256": "f488707fff07b9049714b38389fe3dbe7c32b6e6bc1e7289a0e56bab571b72b9",
  "quality_note_en": "Automated row checks and AI-assisted primary-source inspection have distinct denominators. The primary studies were selected for complete local evidence; their conflicts do not estimate a whole-database error rate.",
  "quality_note_zh": "自动记录检查和AI辅助原文复核具有不同分母。原文案例按本地证据完整性选择，其冲突数量不能推算全库错误率。",
  "source_origin_addendum": {
    "current_evidence_origin": "simulation_reconstructible",
    "experimental_evidence_eligible": false,
    "group": "PRJNA321551/HeLa",
    "historical_import_origin": "unresolved_original_job_log_missing",
    "included_in_historical_source_retained_totals": true,
    "other_catalogue_origins_revalidated_by_this_update": false,
    "retained_candidates": 10000,
    "retained_round_records": 11,
    "sequence_round_observations": 110000,
    "url": "/web/source-evidence/hela"
  },
  "version": "publication-coverage-20261016-r1"
}