{"cases":[{"artifacts":[{"label":{"en":"Source objects and import gaps","zh":"来源对象与导入缺口表"},"path":"hela-source-object-map.tsv"},{"label":{"en":"Round-by-round count comparison","zh":"逐轮计数对照表"},"path":"hela-round-correspondence.tsv"},{"label":{"en":"110000 observation correspondences","zh":"110000条观测对应表"},"path":"lineage.tsv.gz"},{"label":{"en":"Origin counts and scope","zh":"来源分项计数与范围"},"path":"hela-resolution.json"}],"counts":{"reconstructed_simulation_observations":110000,"retained_candidate_records":10000,"retained_round_records":11,"sequence_round_observations":110000,"unresolved_observations":110000},"docking_supported":false,"evidence":[{"claim":{"en":"Official archive separates experimental and virtual SELEX objects","zh":"官方归档区分实验与虚拟SELEX对象"},"selector":"19 experiment records; 8 hela_* and 11 aptasim_* libraries","url":"https://www.ebi.ac.uk/ena/browser/view/PRJNA321551"},{"claim":{"en":"Complete retained-value reconstruction and independent verification","zh":"全部保留数值的重建与独立验算"},"selector":"11 files, 110000 observation IDs; exact count comparison","url":"/web/source-evidence/download/hela-round-correspondence.tsv"}],"field_changes":[{"after":"simulation_reconstructible","before":"unresolved_mixed_origin","field":"current_evidence_origin","reason":"110000 exact count matches"},{"after":"unresolved_original_job_log_missing","before":"unresolved","field":"historical_import_origin","reason":"Original import record not recovered"},{"after":false,"before":"unspecified","field":"experimental_evidence_eligible","reason":"Simulation-reconstructible values are not experimental evidence"}],"gaps":[{"en":"The May 2026 import job, exact source-to-import log and original processed table were not recovered.","zh":"未找回2026年5月导入作业、来源文件到导入记录的日志及原始处理表。"},{"en":"The eight experimental objects were not replayed in this targeted comparison; historical mixed contributions have not been excluded.","zh":"本次定点对照未重放8个实验对象，尚不能排除历史导入时存在混合贡献。"}],"key":"hela","material":{"label":{"en":"HeLa cell-selection context and separate AptaSim benchmark","zh":"HeLa细胞筛选背景与独立AptaSim模拟数据"}},"original_target":{"bioproject":"PRJNA321551","description":"aptasim_round0; aptasim_round1 · 9 Rounds of Cell-SELEX against Hela Cells · 19 runs in PRJNA321551","ensembl_gene_id":null,"id":2632,"n_affinity_records":0,"n_rounds":11,"n_sequences":10000,"na_type":"DNA","organism":null,"partner_uniprot_id":null,"rounds_available":"R0,R1,R2,R3,R4,R5,R6,R7,R8,R9,R10","source":"PRJNA321551","target_category":"cell","target_name":"HeLa","uniprot_id":null},"project":"PRJNA321551","reference":{"accession":null,"relation":"CCR7 cell context; no purified-protein assignment"},"status":{"en":"Simulation correspondence reconstructed; original import log missing","zh":"模拟数值对应已重建；原导入日志仍缺"},"summary":{"en":"All 110,000 retained count values are exactly reproducible from 11 AptaSim source objects. These same rows are excluded from experimental evidence; their historical import provenance remains unresolved.","zh":"110,000条保留观测的计数均由11个AptaSim模拟对象精确重建。同一批记录不作为实验依据，历史导入来源仍未恢复；这两项状态描述的是同一批记录。"},"target_id":2632,"target_projection":{"current_evidence_origin":"simulation_reconstructible","experimental_evidence_eligible":false,"historical_import_origin":"unresolved_original_job_log_missing","na_type_scope":"stored_candidate_encoding_with_separate_origin_evidence","source_library_type":"mixed_experimental_RNA_and_simulated_DNA"},"title":{"en":"HeLa: observation origins","zh":"HeLa：观测来源"}},{"artifacts":[{"label":{"en":"Material and source relationships","zh":"材料与来源关系"},"path":"mouse-st2-material.json"},{"label":{"en":"Evidence positions and field corrections","zh":"证据位置与字段修正"},"path":"mouse-st2-evidence.json"}],"counts":{"archive_run_objects":10,"retained_candidate_records":6410,"retained_round_records":8,"sequence_round_observations":51280},"docking_supported":false,"evidence":[{"claim":{"en":"Primary article identifies mouse Fc-chimera material","zh":"主文明确鼠源Fc嵌合材料"},"selector":".//sec[@id='SEC2-8']/p[2] (mouse ST2/IL-33R catalogue 1004-MR); p[4] (Fc chimera)","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12802916/"},{"claim":{"en":"Author supplement confirms catalogue 1004-MR","zh":"作者附件确认1004-MR"},"selector":"PDF page 2, Supplementary Text 2.2.2 Dataset B; lines 87-95","url":"https://academic.oup.com/nar/article/54/2/gkaf1480/8425320#supplementary-data"},{"claim":{"en":"Archive sample names mouse ST2","zh":"归档样本明确鼠ST2"},"selector":"/SAMPLE_SET/SAMPLE[@accession='SAMD00829922']/DESCRIPTION; SAMPLE_NAME/TAXON_ID","url":"https://www.ebi.ac.uk/ena/browser/view/SAMD00829922"},{"claim":{"en":"Official mouse reference identity","zh":"官方鼠源参考身份"},"selector":"primaryAccession; organism.scientificName/taxonId; genes[0].geneName; proteinDescription.alternativeNames","url":"https://www.uniprot.org/uniprotkb/P14719/entry"}],"field_changes":[{"after":"material:PRJDB19137:mouse-st2-1004-mr","before":null,"field":"source_material_id","reason":"archive_sample, article_material, supplement_material"},{"after":"Mus musculus (10090)","before":null,"field":"normalized_target_species","reason":"archive_sample, article_material"},{"after":"Recombinant mouse ST2/IL-33R Fc chimera (R&D Systems 1004-MR)","before":"ST2","field":"normalized_target_label","reason":"article_material, supplement_material"},{"after":"RNA","before":"DNA","field":"normalized_na_type","reason":"archive_project, supplement_material"},{"after":"P14719","before":"Q01638","field":"normalized_reference_uniprot_id","reason":"mouse_reference"},{"after":"Q01638","before":"Q01638","field":"legacy_target.uniprot_id","reason":"legacy_error"},{"after":false,"before":false,"field":"registry:0303_positive_link","reason":"legacy_error, archive_sample"},{"after":"resolved_source_qualified_mouse_material","before":"species_reference_conflict","field":"resolution_status","reason":"archive_sample, article_material, supplement_material"},{"after":[6410,8,51280],"before":[6410,8,51280],"field":"retained_counts","reason":""}],"gaps":[{"en":"Exact assay construct boundaries, lot and post-translational state remain unreported.","zh":"精确构建体边界、批次和翻译后状态仍未报告。"}],"key":"st2","material":{"catalogue_number":"1004-MR","entity_type":"recombinant_protein_chimera","label":{"en":"Source-reported recombinant mouse ST2/IL-33R Fc chimera","zh":"来源报告的重组鼠 ST2/IL-33R Fc 嵌合蛋白"},"manufacturer":"R&D Systems","source_reported_tag_or_fusion":"Fc chimera","target_species":{"evidence_ids":["archive_sample","article_material"],"evidence_status":"source_reported","scientific_name":"Mus musculus","taxon_id":10090}},"original_target":{"bioproject":"PRJDB19137","description":"RAPT19-0R; RAPT19-1R · Synthetic oligonucleotides · 10 runs in PRJDB19137","ensembl_gene_id":null,"id":71,"n_affinity_records":0,"n_rounds":8,"n_sequences":6410,"na_type":"DNA","organism":null,"partner_uniprot_id":null,"rounds_available":"R0,R1,R2,R3,R4,R5,R6,R7","source":"PRJDB19137","target_category":"protein","target_name":"ST2","uniprot_id":"Q01638"},"project":"PRJDB19137","reference":{"accession":"P14719","gene":"Il1rl1","organism":"Mus musculus","relation":{"en":"External gene/species reference; author-reported accession absent","zh":"外部基因／物种参考；作者未报告accession"}},"status":{"en":"Source-qualified mouse material resolved","zh":"鼠源材料对应已核清"},"summary":{"en":"The source reports recombinant mouse ST2/IL-33R Fc chimera, R&D Systems 1004-MR. P14719 is an external mouse gene/species reference.","zh":"来源报告重组鼠ST2/IL-33R Fc嵌合蛋白，R&D Systems 1004-MR；P14719为外部鼠源基因／物种参考。"},"target_id":71,"target_projection":{"material_id":"material:PRJDB19137:mouse-st2-1004-mr","na_type":"RNA","na_type_scope":"source_reported_selection_library_not_per_sequence_chemical_identity","organism":"Mus musculus","reference_scope":"external_mouse_gene_species_reference_not_exact_construct","source_library_type":"RNA","target_material_type":"recombinant_protein_chimera","uniprot_id":"P14719"},"title":{"en":"Mouse ST2: assay material and reference","zh":"鼠ST2：实验材料与参考身份"}},{"artifacts":[{"label":{"en":"Registration proposal 0678","zh":"0678登记提案"},"path":"il10ra-registration-proposal.json"},{"label":{"en":"Evidence index","zh":"证据索引"},"path":"il10ra-evidence.tsv"},{"label":{"en":"677-entry equivalence check","zh":"677条登记等价排查"},"path":"il10ra-equivalence-review.json"}],"counts":{"retained_candidate_records":10000,"retained_round_records":2,"sequence_round_observations":20000},"docking_supported":false,"evidence":[{"claim":{"en":"Human IL-10RA-Fc and RNA library reported","zh":"来源报告人IL-10RA-Fc及RNA文库"},"selector":"Methods: material preparation and RNA selection","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4499151/"},{"claim":{"en":"Archive identifies fusion material and pooled rounds","zh":"归档明确融合材料及混合轮次"},"selector":"Experiment title; SRR3279660 pools rounds 1–4","url":"https://www.ebi.ac.uk/ena/browser/view/SRX1653574"},{"claim":{"en":"External human gene/species reference","zh":"外部人源基因／物种参考"},"selector":"Gene IL10RA; human taxonomy 9606","url":"https://www.uniprot.org/uniprotkb/Q13651/entry"}],"field_changes":[{"after":"IL10RA/Q13651/human","before":null,"field":"registry_reference_entity","reason":"677-entry registry equivalence review found no existing entity"},{"after":"source-reported human IL-10RA-Fc fusion protein","before":"legacy label IL-10RA; construct unspecified","field":"assayed_material","reason":"primary methods and both archive experiment titles agree"},{"after":"source_qualified_selection_material","before":null,"field":"source_group.registry_relation","reason":"source project and legacy group identity agree"},{"after":"RNA","before":"DNA","field":"source_library_classification","reason":"primary method reports recovered RNA and in vitro transcription; imported DNA retained as source history"},{"after":"labels retained with pooled archive qualification","before":"retained labels L0,R5","field":"canonical_round_mapping","reason":"SRR3279660 pools source rounds 1–4 and SRR3279661 is source round 5; no barcode-level retained mapping accepted"}],"gaps":[{"en":"Exact Fc-fusion construct boundaries, catalogue, lot and sequence identity are not established.","zh":"精确Fc融合构建体边界、产品编号、批次和序列身份仍未确定。"},{"en":"Q13651 is a gene/species reference, not an accession explicitly assigned to the fusion construct in the checked paper.","zh":"Q13651是基因／物种参考，原文未将其直接指定为该融合构建体的编号。"},{"en":"Archive run/barcode/fraction to retained candidate or observation mapping remains incomplete; control-binding candidates may be present.","zh":"归档运行、条码和筛选组分到保留候选的对应尚未完成，可能包含对照结合候选。"},{"en":"No independent human scientific approval or source-rights approval is supplied by this metadata review.","zh":"本次元数据核对没有代替真人科学与来源权利审核。"}],"key":"il10ra","material":{"catalogue_number":null,"construct_boundaries":null,"fusion_component":"Fc","kind":"source_reported_protein_fusion","lot":null,"missing_reasons":{"catalogue_number":"not_reported_in_checked_primary_evidence","construct_boundaries":"not_reported_in_checked_primary_evidence","lot":"not_reported_in_checked_primary_evidence","sequence_identity":"not_established"},"organism_taxid":"9606","sequence_identity":null,"source_name":"human IL-10RA-Fc fusion protein","species":"Homo sapiens","supplier":"Novus Biologicals","target_component":"human IL-10RA"},"original_target":{"bioproject":"PRJNA315881","description":"IL10RA_1_4; IL10RA_5 · 5 rounds of HT-SELEX against Human Il10RA protein · 2 runs in PRJNA315881","ensembl_gene_id":null,"id":2631,"n_affinity_records":0,"n_rounds":2,"n_sequences":10000,"na_type":"DNA","organism":"Homo sapiens","partner_uniprot_id":null,"rounds_available":"L0,R5","source":"PRJNA315881","target_category":"protein","target_name":"IL-10RA","uniprot_id":"Q13651"},"project":"PRJNA315881","reference":{"accession":"Q13651","database":"UniProtKB","exact_assayed_construct_identity_verified":false,"gene":"IL10RA","organism":"Homo sapiens","paper_explicit_accession":null,"reference_identity_verified":false,"relation":"gene_and_species_reference_for_source_named_fusion_material","taxon_id":"9606"},"status":{"en":"Source-qualified proposal prepared","zh":"来源限定登记提案已备齐"},"summary":{"en":"Primary methods and archive experiments report human IL-10RA-Fc. Q13651 is a human IL10RA reference; the historical 677-entry registry has no equivalent entry.","zh":"原文方法和归档实验均报告人IL-10RA-Fc；Q13651是人IL10RA参考，历史677条登记未发现等价项。"},"target_id":2631,"target_projection":{"na_type":"RNA","na_type_scope":"source_reported_selection_library_not_per_sequence_chemical_identity","proposed_registry_id":"registry:0678","reference_scope":"gene_species_reference_for_Fc_fusion","source_library_type":"RNA","target_material_type":"source_reported_protein_fusion"},"title":{"en":"IL-10RA: registration proposal","zh":"IL-10RA：新增登记提案"}},{"artifacts":[{"label":{"en":"Registration proposal 0679","zh":"0679登记提案"},"path":"ndm1-registration-proposal.json"},{"label":{"en":"Evidence index","zh":"证据索引"},"path":"ndm1-evidence.tsv"},{"label":{"en":"677-entry equivalence check","zh":"677条登记等价排查"},"path":"ndm1-equivalence-review.json"}],"counts":{"retained_candidate_records":10000,"retained_round_records":4,"sequence_round_observations":40000},"docking_supported":false,"evidence":[{"claim":{"en":"Author-reported tagged material and ambiguous provenance","zh":"作者报告的标签材料与含义不清的来历"},"selector":"Methods > Target preparation > first paragraph, first sentence","url":"https://www.nature.com/articles/s41598-022-12062-2"},{"claim":{"en":"External reference species differs from unresolved assay provenance","zh":"外部参考物种与尚未明确的实验材料来源分别保留"},"selector":"Reference identity metadata only; not an assay construct match","url":"https://www.uniprot.org/uniprotkb/C7C422/entry"}],"field_changes":[{"after":"source_named_material_registration_proposal","before":"entry_absent","field":"registry_relation","reason":"Primary article material name, explicit project linkage, and 677-row equivalence audit."},{"after":null,"before":"Klebsiella pneumoniae","field":"assayed_protein_source_organism","reason":"Author wording derived from E. coli is ambiguous; Klebsiella belongs to the external reference entry."},{"after":null,"before":null,"field":"reported_expression_host","reason":"No explicit expression-host statement for the purchased NDM-1 material was identified."},{"after":"C7C422 external reference candidate; not author-reported or construct-verified","before":"C7C422 without qualification","field":"reference_accession_relation","reason":"Official reference metadata plus unapproved free-text resolution provenance."}],"gaps":[{"en":"Exact purchased construct accession or supplier lot/catalogue identity is not reported in the reviewed material paragraph.","zh":"所核查材料段未报告购买构建体的精确编号或供应商批次／产品标识。"},{"en":"Natural protein source species and expression/preparation host are not distinguished by the author phrase derived from E. coli.","zh":"作者derived from E. coli的措辞未区分天然蛋白来源与表达／制备宿主。"},{"en":"Exact assayed-construct equivalence to C7C422 has not been established.","zh":"尚未建立实际实验构建体与C7C422的精确对应。"}],"key":"ndm1","material":{"accession_scan":{"matches_in_article_xml":0,"term":"C7C422"},"assayed_material_accession_reported":null,"assayed_protein_source_organism":null,"data_availability_locator":"Data availability > SRA accession statement","data_availability_project":"PRJNA830749","doi":"10.1038/s41598-022-12062-2","library_type_locator":"Abstract and Methods > Nucleic acid preparation","library_type_reported":"DNA","material_locator":"Methods > Target preparation > first paragraph, first sentence","material_name":"N-terminally hexa-HIS-tagged NDM-1","organism_missing_reason":"not_reported_or_ambiguous: derived from E. coli does not distinguish natural source organism from expression or preparation provenance","pmcid":"PMC9106695","reported_expression_host":null,"source_capture_retrieved_at":"2026-09-16T01:39:22.597263+00:00","source_capture_sha256":"8e0f5adc46b96a98e8f6accb8510391233c2482ef06e82f90d580ef29df8c375","source_reported_material_provenance_text":"NDM-1 (derived from E. coli)","source_url":"https://www.nature.com/articles/s41598-022-12062-2","supplier_reported":"Hölzel Diagnostica Handels GmbH"},"original_target":{"bioproject":"PRJNA830749","description":"SR10.1; SR11.1 · FASTQ-Data of selection rounds 10.1, 11.1, 11.1_control, 13.1, 14.1, 14.1_control, 14.2_Mask, 14.2_Mask_Control · 8 runs in PRJNA830749","ensembl_gene_id":null,"id":2633,"n_affinity_records":0,"n_rounds":4,"n_sequences":10000,"na_type":"DNA","organism":"Klebsiella pneumoniae","partner_uniprot_id":null,"rounds_available":"R10,R11,R13,R14","source":"PRJNA830749","target_category":"protein","target_name":"NDM-1","uniprot_id":"C7C422"},"project":"PRJNA830749","reference":{"accession":"C7C422","author_reported_accession":false,"database":"UniProtKB","entry_name":"BLAN1_KLEPN","exact_assayed_construct_identity_verified":false,"legacy_resolution":"free_text_automatic_candidate_unapproved","reference_organism":"Klebsiella pneumoniae","reference_taxid":573,"relation_to_assayed_material":"external_name_correspondence_not_exact_construct_identity"},"status":{"en":"Material proposal prepared; reference correspondence unresolved","zh":"材料登记提案已备齐；参考对应仍有限定"},"summary":{"en":"The source reports His-tagged NDM-1. Its provenance wording does not establish natural source species or expression host. C7C422 came from an unapproved automatic name match.","zh":"来源报告His标签NDM-1；其材料来历描述不能确定天然来源物种或表达宿主。C7C422来自未经确认的自动名称匹配。"},"target_id":2633,"target_projection":{"na_type_scope":"source_reported_selection_library","organism":null,"proposed_registry_id":"registry:0679","reference_candidates":[{"accession":"C7C422","author_reported_accession":false,"database":"UniProtKB","entry_name":"BLAN1_KLEPN","exact_assayed_construct_identity_verified":false,"legacy_resolution":"free_text_automatic_candidate_unapproved","reference_organism":"Klebsiella pneumoniae","reference_taxid":573,"relation_to_assayed_material":"external_name_correspondence_not_exact_construct_identity"}],"reference_scope":"unapproved_external_name_correspondence","source_library_type":"DNA","target_material_type":"source_reported_tagged_protein_material","uniprot_id":null},"title":{"en":"NDM-1: registration proposal","zh":"NDM-1：新增登记提案"}}],"manifest_sha256":"4dc88e902da9261201a581c375f3e604eda7d47153ef254494942e5a247b35dd","version":"core-source-evidence-20261024-r1"}