{"artifacts":[{"label":{"en":"Registration proposal 0678","zh":"0678登记提案"},"path":"il10ra-registration-proposal.json"},{"label":{"en":"Evidence index","zh":"证据索引"},"path":"il10ra-evidence.tsv"},{"label":{"en":"677-entry equivalence check","zh":"677条登记等价排查"},"path":"il10ra-equivalence-review.json"}],"counts":{"retained_candidate_records":10000,"retained_round_records":2,"sequence_round_observations":20000},"docking_supported":false,"evidence":[{"claim":{"en":"Human IL-10RA-Fc and RNA library reported","zh":"来源报告人IL-10RA-Fc及RNA文库"},"selector":"Methods: material preparation and RNA selection","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4499151/"},{"claim":{"en":"Archive identifies fusion material and pooled rounds","zh":"归档明确融合材料及混合轮次"},"selector":"Experiment title; SRR3279660 pools rounds 1–4","url":"https://www.ebi.ac.uk/ena/browser/view/SRX1653574"},{"claim":{"en":"External human gene/species reference","zh":"外部人源基因／物种参考"},"selector":"Gene IL10RA; human taxonomy 9606","url":"https://www.uniprot.org/uniprotkb/Q13651/entry"}],"field_changes":[{"after":"IL10RA/Q13651/human","before":null,"field":"registry_reference_entity","reason":"677-entry registry equivalence review found no existing entity"},{"after":"source-reported human IL-10RA-Fc fusion protein","before":"legacy label IL-10RA; construct unspecified","field":"assayed_material","reason":"primary methods and both archive experiment titles agree"},{"after":"source_qualified_selection_material","before":null,"field":"source_group.registry_relation","reason":"source project and legacy group identity agree"},{"after":"RNA","before":"DNA","field":"source_library_classification","reason":"primary method reports recovered RNA and in vitro transcription; imported DNA retained as source history"},{"after":"labels retained with pooled archive qualification","before":"retained labels L0,R5","field":"canonical_round_mapping","reason":"SRR3279660 pools source rounds 1–4 and SRR3279661 is source round 5; no barcode-level retained mapping accepted"}],"gaps":[{"en":"Exact Fc-fusion construct boundaries, catalogue, lot and sequence identity are not established.","zh":"精确Fc融合构建体边界、产品编号、批次和序列身份仍未确定。"},{"en":"Q13651 is a gene/species reference, not an accession explicitly assigned to the fusion construct in the checked paper.","zh":"Q13651是基因／物种参考，原文未将其直接指定为该融合构建体的编号。"},{"en":"Archive run/barcode/fraction to retained candidate or observation mapping remains incomplete; control-binding candidates may be present.","zh":"归档运行、条码和筛选组分到保留候选的对应尚未完成，可能包含对照结合候选。"},{"en":"No independent human scientific approval or source-rights approval is supplied by this metadata review.","zh":"本次元数据核对没有代替真人科学与来源权利审核。"}],"key":"il10ra","material":{"catalogue_number":null,"construct_boundaries":null,"fusion_component":"Fc","kind":"source_reported_protein_fusion","lot":null,"missing_reasons":{"catalogue_number":"not_reported_in_checked_primary_evidence","construct_boundaries":"not_reported_in_checked_primary_evidence","lot":"not_reported_in_checked_primary_evidence","sequence_identity":"not_established"},"organism_taxid":"9606","sequence_identity":null,"source_name":"human IL-10RA-Fc fusion protein","species":"Homo sapiens","supplier":"Novus Biologicals","target_component":"human IL-10RA"},"original_target":{"bioproject":"PRJNA315881","description":"IL10RA_1_4; IL10RA_5 · 5 rounds of HT-SELEX against Human Il10RA protein · 2 runs in PRJNA315881","ensembl_gene_id":null,"id":2631,"n_affinity_records":0,"n_rounds":2,"n_sequences":10000,"na_type":"DNA","organism":"Homo sapiens","partner_uniprot_id":null,"rounds_available":"L0,R5","source":"PRJNA315881","target_category":"protein","target_name":"IL-10RA","uniprot_id":"Q13651"},"project":"PRJNA315881","reference":{"accession":"Q13651","database":"UniProtKB","exact_assayed_construct_identity_verified":false,"gene":"IL10RA","organism":"Homo sapiens","paper_explicit_accession":null,"reference_identity_verified":false,"relation":"gene_and_species_reference_for_source_named_fusion_material","taxon_id":"9606"},"status":{"en":"Source-qualified proposal prepared","zh":"来源限定登记提案已备齐"},"summary":{"en":"Primary methods and archive experiments report human IL-10RA-Fc. Q13651 is a human IL10RA reference; the historical 677-entry registry has no equivalent entry.","zh":"原文方法和归档实验均报告人IL-10RA-Fc；Q13651是人IL10RA参考，历史677条登记未发现等价项。"},"target_id":2631,"target_projection":{"na_type":"RNA","na_type_scope":"source_reported_selection_library_not_per_sequence_chemical_identity","proposed_registry_id":"registry:0678","reference_scope":"gene_species_reference_for_Fc_fusion","source_library_type":"RNA","target_material_type":"source_reported_protein_fusion"},"title":{"en":"IL-10RA: registration proposal","zh":"IL-10RA：新增登记提案"}}