{"artifacts":[{"label":{"en":"Registration proposal 0679","zh":"0679登记提案"},"path":"ndm1-registration-proposal.json"},{"label":{"en":"Evidence index","zh":"证据索引"},"path":"ndm1-evidence.tsv"},{"label":{"en":"677-entry equivalence check","zh":"677条登记等价排查"},"path":"ndm1-equivalence-review.json"}],"counts":{"retained_candidate_records":10000,"retained_round_records":4,"sequence_round_observations":40000},"docking_supported":false,"evidence":[{"claim":{"en":"Author-reported tagged material and ambiguous provenance","zh":"作者报告的标签材料与含义不清的来历"},"selector":"Methods > Target preparation > first paragraph, first sentence","url":"https://www.nature.com/articles/s41598-022-12062-2"},{"claim":{"en":"External reference species differs from unresolved assay provenance","zh":"外部参考物种与尚未明确的实验材料来源分别保留"},"selector":"Reference identity metadata only; not an assay construct match","url":"https://www.uniprot.org/uniprotkb/C7C422/entry"}],"field_changes":[{"after":"source_named_material_registration_proposal","before":"entry_absent","field":"registry_relation","reason":"Primary article material name, explicit project linkage, and 677-row equivalence audit."},{"after":null,"before":"Klebsiella pneumoniae","field":"assayed_protein_source_organism","reason":"Author wording derived from E. coli is ambiguous; Klebsiella belongs to the external reference entry."},{"after":null,"before":null,"field":"reported_expression_host","reason":"No explicit expression-host statement for the purchased NDM-1 material was identified."},{"after":"C7C422 external reference candidate; not author-reported or construct-verified","before":"C7C422 without qualification","field":"reference_accession_relation","reason":"Official reference metadata plus unapproved free-text resolution provenance."}],"gaps":[{"en":"Exact purchased construct accession or supplier lot/catalogue identity is not reported in the reviewed material paragraph.","zh":"所核查材料段未报告购买构建体的精确编号或供应商批次／产品标识。"},{"en":"Natural protein source species and expression/preparation host are not distinguished by the author phrase derived from E. coli.","zh":"作者derived from E. coli的措辞未区分天然蛋白来源与表达／制备宿主。"},{"en":"Exact assayed-construct equivalence to C7C422 has not been established.","zh":"尚未建立实际实验构建体与C7C422的精确对应。"}],"key":"ndm1","material":{"accession_scan":{"matches_in_article_xml":0,"term":"C7C422"},"assayed_material_accession_reported":null,"assayed_protein_source_organism":null,"data_availability_locator":"Data availability > SRA accession statement","data_availability_project":"PRJNA830749","doi":"10.1038/s41598-022-12062-2","library_type_locator":"Abstract and Methods > Nucleic acid preparation","library_type_reported":"DNA","material_locator":"Methods > Target preparation > first paragraph, first sentence","material_name":"N-terminally hexa-HIS-tagged NDM-1","organism_missing_reason":"not_reported_or_ambiguous: derived from E. coli does not distinguish natural source organism from expression or preparation provenance","pmcid":"PMC9106695","reported_expression_host":null,"source_capture_retrieved_at":"2026-09-16T01:39:22.597263+00:00","source_capture_sha256":"8e0f5adc46b96a98e8f6accb8510391233c2482ef06e82f90d580ef29df8c375","source_reported_material_provenance_text":"NDM-1 (derived from E. coli)","source_url":"https://www.nature.com/articles/s41598-022-12062-2","supplier_reported":"Hölzel Diagnostica Handels GmbH"},"original_target":{"bioproject":"PRJNA830749","description":"SR10.1; SR11.1 · FASTQ-Data of selection rounds 10.1, 11.1, 11.1_control, 13.1, 14.1, 14.1_control, 14.2_Mask, 14.2_Mask_Control · 8 runs in PRJNA830749","ensembl_gene_id":null,"id":2633,"n_affinity_records":0,"n_rounds":4,"n_sequences":10000,"na_type":"DNA","organism":"Klebsiella pneumoniae","partner_uniprot_id":null,"rounds_available":"R10,R11,R13,R14","source":"PRJNA830749","target_category":"protein","target_name":"NDM-1","uniprot_id":"C7C422"},"project":"PRJNA830749","reference":{"accession":"C7C422","author_reported_accession":false,"database":"UniProtKB","entry_name":"BLAN1_KLEPN","exact_assayed_construct_identity_verified":false,"legacy_resolution":"free_text_automatic_candidate_unapproved","reference_organism":"Klebsiella pneumoniae","reference_taxid":573,"relation_to_assayed_material":"external_name_correspondence_not_exact_construct_identity"},"status":{"en":"Material proposal prepared; reference correspondence unresolved","zh":"材料登记提案已备齐；参考对应仍有限定"},"summary":{"en":"The source reports His-tagged NDM-1. Its provenance wording does not establish natural source species or expression host. C7C422 came from an unapproved automatic name match.","zh":"来源报告His标签NDM-1；其材料来历描述不能确定天然来源物种或表达宿主。C7C422来自未经确认的自动名称匹配。"},"target_id":2633,"target_projection":{"na_type_scope":"source_reported_selection_library","organism":null,"proposed_registry_id":"registry:0679","reference_candidates":[{"accession":"C7C422","author_reported_accession":false,"database":"UniProtKB","entry_name":"BLAN1_KLEPN","exact_assayed_construct_identity_verified":false,"legacy_resolution":"free_text_automatic_candidate_unapproved","reference_organism":"Klebsiella pneumoniae","reference_taxid":573,"relation_to_assayed_material":"external_name_correspondence_not_exact_construct_identity"}],"reference_scope":"unapproved_external_name_correspondence","source_library_type":"DNA","target_material_type":"source_reported_tagged_protein_material","uniprot_id":null},"title":{"en":"NDM-1: registration proposal","zh":"NDM-1：新增登记提案"}}