[ { "change_proposal": [ { "after": "IL10RA/Q13651/human", "before": null, "field": "registry_reference_entity", "reason": "677-entry registry equivalence review found no existing entity" }, { "after": "source-reported human IL-10RA-Fc fusion protein", "before": "legacy label IL-10RA; construct unspecified", "field": "assayed_material", "reason": "primary methods and both archive experiment titles agree" }, { "after": "source_qualified_selection_material", "before": null, "field": "source_group.registry_relation", "reason": "source project and legacy group identity agree" }, { "after": "RNA", "before": "DNA", "field": "source_library_classification", "reason": "primary method reports recovered RNA and in vitro transcription; imported DNA retained as source history" }, { "after": "labels retained with pooled archive qualification", "before": "retained labels L0,R5", "field": "canonical_round_mapping", "reason": "SRR3279660 pools source rounds 1–4 and SRR3279661 is source round 5; no barcode-level retained mapping accepted" } ], "display_name": { "en": "Human IL-10 receptor alpha — source-reported Fc fusion", "zh": "人 IL-10 受体 α：来源报告的 Fc 融合材料" }, "evidence_ids": [ "IL10RA-E1", "IL10RA-E2", "IL10RA-E3", "IL10RA-E4", "IL10RA-E5", "IL10RA-E6", "IL10RA-E7" ], "evidence_origin_bundle": { "manifest_sha256": "d4a5ed01dea4c451e98420844e5931f580eba45fe5b8eba10a4731d5028044a7", "name": "il10ra-registration-evidence-20261024-r1" }, "format": "panapta-source-qualified-registration-proposal/v1", "impact": { "canonical_db_modified": false, "historical_registry_entries": 677, "new_independent_experimental_targets_claimed": false, "proposed_new_registry_entities": 1, "public_runtime_modified": false, "publication_counts_modified": false, "retained_candidate_or_observation_counts_change": false }, "material": { "catalogue_number": null, "construct_boundaries": null, "fusion_component": "Fc", "kind": "source_reported_protein_fusion", "lot": null, "missing_reasons": { "catalogue_number": "not_reported_in_checked_primary_evidence", "construct_boundaries": "not_reported_in_checked_primary_evidence", "lot": "not_reported_in_checked_primary_evidence", "sequence_identity": "not_established" }, "organism_taxid": "9606", "sequence_identity": null, "source_name": "human IL-10RA-Fc fusion protein", "species": "Homo sapiens", "supplier": "Novus Biologicals", "target_component": "human IL-10RA" }, "name": "IL10RA", "proposal_status": "evidence_complete_for_source_qualified_registry_addition", "reference": { "accession": "Q13651", "database": "UniProtKB", "exact_assayed_construct_identity_verified": false, "gene": "IL10RA", "organism": "Homo sapiens", "paper_explicit_accession": null, "reference_identity_verified": false, "relation": "gene_and_species_reference_for_source_named_fusion_material", "taxon_id": "9606" }, "registry_id_assignment": "proposed; root integrator assigns across parallel additions", "remaining_gaps": [ "Exact Fc-fusion construct boundaries, catalogue, lot and sequence identity are not established.", "Q13651 is a gene/species reference, not an accession explicitly assigned to the fusion construct in the checked paper.", "Archive run/barcode/fraction to retained candidate or observation mapping remains incomplete; control-binding candidates may be present.", "No independent human scientific approval or source-rights approval is supplied by this metadata review." ], "retained_counts": { "all_candidates_target_specific": false, "candidate_records": 10000, "counts_changed": false, "retained_group_round_records": 2, "round_count_scope": "retained archive grouping labels L0 and R5; not two canonical experimental rounds", "sequence_round_observations": 20000, "source_group_cap": 10000 }, "review_status": { "metadata_evidence": "machine_checked_with_source_positions", "rights": "human_review_pending", "science": "human_review_pending" }, "source_group_relation": { "candidate_assignment_to_registered_reference_approved": false, "direct_connection_permitted": true, "experiment_ids": [ "SRX1653574", "SRX1653575" ], "kind": "source_qualified_selection_material", "material_identity_fully_adjudicated": false, "project": "PRJNA315881", "run_ids": [ "SRR3279660", "SRR3279661" ], "source_component_or_fraction_assignment_complete": false, "study": "SRP072180", "supports_registered_reference": false, "target_fraction_specific_candidate_status": "not_adjudicated", "target_id": 2631 }, "source_library_classification": { "chemical_modification": null, "original_imported_value": "DNA", "per_sequence_chemistry_assigned": false, "scope": "reported selection library; sequencing reads derive from cDNA", "source_reported_value": "RNA" }, "suggested_registry_id": "registry:0678", "version": "il10ra-registration-evidence-20261024-r1" }, { "aliases": [ "NDM-1", "NDM1", "blaNDM-1", "New Delhi metallo-beta-lactamase-1", "Metallo-beta-lactamase type 2" ], "automatic_alias_merging_authorized": false, "entity_type": "source_reported_tagged_protein_material", "evidence_origin_bundle": { "locator_scope": "Artifact names refer to this source evidence package, not the integrated download directory.", "manifest_sha256": "e4fd97eac9c2f406d8e16e8f728fdf99cc0d06542bb1b2336874e3de900b4351", "name": "ndm1-registration-evidence-20261024-r1" }, "field_proposals": [ { "basis": "Primary article material name, explicit project linkage, and 677-row equivalence audit.", "field": "registry_relation", "old": "entry_absent", "proposed": "source_named_material_registration_proposal" }, { "basis": "Author wording derived from E. coli is ambiguous; Klebsiella belongs to the external reference entry.", "field": "assayed_protein_source_organism", "missing_reason": "not_reported_or_ambiguous", "old_legacy_target_value": "Klebsiella pneumoniae", "proposed": null }, { "basis": "No explicit expression-host statement for the purchased NDM-1 material was identified.", "field": "reported_expression_host", "missing_reason": "not_reported_or_ambiguous", "proposed": null }, { "basis": "Official reference metadata plus unapproved free-text resolution provenance.", "field": "reference_accession_relation", "old_legacy_value": "C7C422 without qualification", "proposed": "C7C422 external reference candidate; not author-reported or construct-verified" } ], "identity_aliases": [ "NDM-1", "NDM1", "blaNDM-1", "New Delhi metallo-beta-lactamase-1" ], "integration_constraints": { "canonical_registry_mutated": false, "historical_677_registry_preserved": true, "public_site_mutated": false }, "material": { "accession_scan": { "matches_in_article_xml": 0, "term": "C7C422" }, "assayed_material_accession_reported": null, "assayed_protein_source_organism": null, "data_availability_locator": "Data availability > SRA accession statement", "data_availability_project": "PRJNA830749", "doi": "10.1038/s41598-022-12062-2", "library_type_locator": "Abstract and Methods > Nucleic acid preparation", "library_type_reported": "DNA", "material_locator": "Methods > Target preparation > first paragraph, first sentence", "material_name": "N-terminally hexa-HIS-tagged NDM-1", "organism_missing_reason": "not_reported_or_ambiguous: derived from E. coli does not distinguish natural source organism from expression or preparation provenance", "pmcid": "PMC9106695", "reported_expression_host": null, "source_capture_retrieved_at": "2026-09-16T01:39:22.597263+00:00", "source_capture_sha256": "8e0f5adc46b96a98e8f6accb8510391233c2482ef06e82f90d580ef29df8c375", "source_reported_material_provenance_text": "NDM-1 (derived from E. coli)", "source_url": "https://www.nature.com/articles/s41598-022-12062-2", "supplier_reported": "Hölzel Diagnostica Handels GmbH" }, "proposal_id": "ndm1-registration-20261024-r1", "proposed_name": "NDM-1", "proposed_registry_id": "registry:0679", "reference": { "accession": "C7C422", "author_reported_accession": false, "database": "UniProtKB", "entry_name": "BLAN1_KLEPN", "exact_assayed_construct_identity_verified": false, "legacy_resolution": "free_text_automatic_candidate_unapproved", "reference_organism": "Klebsiella pneumoniae", "reference_taxid": 573, "relation_to_assayed_material": "external_name_correspondence_not_exact_construct_identity" }, "reference_display_names": [ "Metallo-beta-lactamase type 2" ], "remaining_gaps": [ "Exact purchased construct accession or supplier lot/catalogue identity is not reported in the reviewed material paragraph.", "Natural protein source species and expression/preparation host are not distinguished by the author phrase derived from E. coli.", "Exact assayed-construct equivalence to C7C422 has not been established." ], "review_status": { "rights": "human_review_pending", "science": "human_review_pending", "technical_metadata_evidence": "checked" }, "schema": "panapta-source-qualified-registration-proposal/v1", "scope": "identity_and_source_metadata_only", "sequence_content_included": false, "source_bundle_artifacts": [ "article-identity-metadata.json", "uniprot-identity-only.tsv", "uniprot-identity-receipt.json", "archive-identity-metadata.json", "equivalence-audit.json", "legacy-reference-resolution.json", "old-target-metadata.json" ], "source_target_association": { "candidate_assignment_to_registered_reference_approved": false, "count_scope": "existing retained source-group counts; no recounted or newly processed sequence data", "doi": "10.1038/s41598-022-12062-2", "material_identity_fully_adjudicated": false, "project": "PRJNA830749", "relation": "source_named_assayed_protein_material", "retained_candidate_records": 10000, "retained_round_records": 4, "sequence_round_observations": 40000, "source_name_supported": true, "target_id": 2633 }, "status": "source_qualified_registration_proposal_ready" } ]