{
  "change_proposal": [
    {
      "after": "IL10RA/Q13651/human",
      "before": null,
      "field": "registry_reference_entity",
      "reason": "677-entry registry equivalence review found no existing entity"
    },
    {
      "after": "source-reported human IL-10RA-Fc fusion protein",
      "before": "legacy label IL-10RA; construct unspecified",
      "field": "assayed_material",
      "reason": "primary methods and both archive experiment titles agree"
    },
    {
      "after": "source_qualified_selection_material",
      "before": null,
      "field": "source_group.registry_relation",
      "reason": "source project and legacy group identity agree"
    },
    {
      "after": "RNA",
      "before": "DNA",
      "field": "source_library_classification",
      "reason": "primary method reports recovered RNA and in vitro transcription; imported DNA retained as source history"
    },
    {
      "after": "labels retained with pooled archive qualification",
      "before": "retained labels L0,R5",
      "field": "canonical_round_mapping",
      "reason": "SRR3279660 pools source rounds 1–4 and SRR3279661 is source round 5; no barcode-level retained mapping accepted"
    }
  ],
  "display_name": {
    "en": "Human IL-10 receptor alpha — source-reported Fc fusion",
    "zh": "人 IL-10 受体 α：来源报告的 Fc 融合材料"
  },
  "evidence_ids": [
    "IL10RA-E1",
    "IL10RA-E2",
    "IL10RA-E3",
    "IL10RA-E4",
    "IL10RA-E5",
    "IL10RA-E6",
    "IL10RA-E7"
  ],
  "evidence_origin_bundle": {
    "manifest_sha256": "d4a5ed01dea4c451e98420844e5931f580eba45fe5b8eba10a4731d5028044a7",
    "name": "il10ra-registration-evidence-20261024-r1"
  },
  "format": "panapta-source-qualified-registration-proposal/v1",
  "impact": {
    "canonical_db_modified": false,
    "historical_registry_entries": 677,
    "new_independent_experimental_targets_claimed": false,
    "proposed_new_registry_entities": 1,
    "public_runtime_modified": false,
    "publication_counts_modified": false,
    "retained_candidate_or_observation_counts_change": false
  },
  "material": {
    "catalogue_number": null,
    "construct_boundaries": null,
    "fusion_component": "Fc",
    "kind": "source_reported_protein_fusion",
    "lot": null,
    "missing_reasons": {
      "catalogue_number": "not_reported_in_checked_primary_evidence",
      "construct_boundaries": "not_reported_in_checked_primary_evidence",
      "lot": "not_reported_in_checked_primary_evidence",
      "sequence_identity": "not_established"
    },
    "organism_taxid": "9606",
    "sequence_identity": null,
    "source_name": "human IL-10RA-Fc fusion protein",
    "species": "Homo sapiens",
    "supplier": "Novus Biologicals",
    "target_component": "human IL-10RA"
  },
  "name": "IL10RA",
  "proposal_status": "evidence_complete_for_source_qualified_registry_addition",
  "reference": {
    "accession": "Q13651",
    "database": "UniProtKB",
    "exact_assayed_construct_identity_verified": false,
    "gene": "IL10RA",
    "organism": "Homo sapiens",
    "paper_explicit_accession": null,
    "reference_identity_verified": false,
    "relation": "gene_and_species_reference_for_source_named_fusion_material",
    "taxon_id": "9606"
  },
  "registry_id_assignment": "proposed; root integrator assigns across parallel additions",
  "remaining_gaps": [
    "Exact Fc-fusion construct boundaries, catalogue, lot and sequence identity are not established.",
    "Q13651 is a gene/species reference, not an accession explicitly assigned to the fusion construct in the checked paper.",
    "Archive run/barcode/fraction to retained candidate or observation mapping remains incomplete; control-binding candidates may be present.",
    "No independent human scientific approval or source-rights approval is supplied by this metadata review."
  ],
  "retained_counts": {
    "all_candidates_target_specific": false,
    "candidate_records": 10000,
    "counts_changed": false,
    "retained_group_round_records": 2,
    "round_count_scope": "retained archive grouping labels L0 and R5; not two canonical experimental rounds",
    "sequence_round_observations": 20000,
    "source_group_cap": 10000
  },
  "review_status": {
    "metadata_evidence": "machine_checked_with_source_positions",
    "rights": "human_review_pending",
    "science": "human_review_pending"
  },
  "source_group_relation": {
    "candidate_assignment_to_registered_reference_approved": false,
    "direct_connection_permitted": true,
    "experiment_ids": [
      "SRX1653574",
      "SRX1653575"
    ],
    "kind": "source_qualified_selection_material",
    "material_identity_fully_adjudicated": false,
    "project": "PRJNA315881",
    "run_ids": [
      "SRR3279660",
      "SRR3279661"
    ],
    "source_component_or_fraction_assignment_complete": false,
    "study": "SRP072180",
    "supports_registered_reference": false,
    "target_fraction_specific_candidate_status": "not_adjudicated",
    "target_id": 2631
  },
  "source_library_classification": {
    "chemical_modification": null,
    "original_imported_value": "DNA",
    "per_sequence_chemistry_assigned": false,
    "scope": "reported selection library; sequencing reads derive from cDNA",
    "source_reported_value": "RNA"
  },
  "suggested_registry_id": "registry:0678",
  "version": "il10ra-registration-evidence-20261024-r1"
}