{
  "schema_version": "panapta-material-evidence-resolution/v1",
  "target_id": 71,
  "project": "PRJDB19137",
  "material_record": {
    "schema_version": "panapta-source-qualified-material/v1",
    "material_id": "material:PRJDB19137:mouse-st2-1004-mr",
    "label": {
      "en": "Source-reported recombinant mouse ST2/IL-33R Fc chimera",
      "zh": "来源报告的重组鼠 ST2/IL-33R Fc 嵌合蛋白"
    },
    "entity_type": "recombinant_protein_chimera",
    "target_name": "ST2/IL-33R",
    "target_species": {
      "scientific_name": "Mus musculus",
      "taxon_id": 10090,
      "evidence_status": "source_reported",
      "evidence_ids": [
        "archive_sample",
        "article_material"
      ]
    },
    "manufacturer": "R&D Systems",
    "catalogue_number": "1004-MR",
    "source_reported_tag_or_fusion": "Fc chimera",
    "source_reported_reference_accession": null,
    "source_reported_reference_accession_missing_reason": "not_reported",
    "external_mouse_reference": {
      "accession": "P14719",
      "database": "UniProtKB",
      "taxon_id": 10090,
      "organism": "Mus musculus",
      "gene": "Il1rl1",
      "status": "external_species_gene_reference_verified",
      "author_reported_accession": false,
      "exact_assay_construct_equivalence_verified": false,
      "evidence_ids": [
        "mouse_reference",
        "article_material",
        "archive_sample"
      ]
    },
    "catalogue_specification_is_assayed_batch_certificate": false,
    "exact_assayed_construct_identity_verified": false,
    "construct_details": {
      "lot_number": null,
      "amino_acid_boundaries_author_reported": null,
      "exact_assayed_protein_sequence": null,
      "post_translational_state": null
    },
    "construct_missing_reasons": {
      "lot_number": "not_reported",
      "amino_acid_boundaries_author_reported": "not_reported",
      "exact_assayed_protein_sequence": "not_reported",
      "post_translational_state": "not_reported"
    },
    "library_classification": {
      "source_reported": "RNA",
      "archive_sequenced_material": "synthetic construct",
      "archive_taxon_id": 32630,
      "complete_candidate_chemical_identity_verified": false,
      "evidence_ids": [
        "archive_project",
        "supplement_material"
      ]
    },
    "source_group": {
      "legacy_target_id": 71,
      "project": "PRJDB19137",
      "study": "DRP012519",
      "submission": "DRA019609",
      "dataset": "B",
      "biosample": "SAMD00829922"
    },
    "relationship": {
      "type": "source_qualified_assay_material",
      "target_id": 71,
      "material_id": "material:PRJDB19137:mouse-st2-1004-mr",
      "registry_id": null,
      "registry_id_missing_reason": "mouse_material_not_a_member_of_historical_677_registry",
      "human_reference_registry_id": "registry:0303",
      "human_reference_accession": "Q01638",
      "human_reference_relation_status": "rejected_species_mismatch",
      "restore_human_reference_link": false
    },
    "counts": {
      "retained_candidate_records": 6410,
      "retained_round_records": 8,
      "sequence_round_observations": 51280,
      "archive_run_objects": 10,
      "counts_scope": "existing target-group records; no full-archive or independent-target claim",
      "independent_molecular_targets": null,
      "target_specific_read_records": null
    },
    "docking": {
      "single_canonical_protein_assignment_eligible": false,
      "reason": "source_reports_an_Fc_chimera_and_exact_assayed_construct_is_unresolved"
    },
    "evidence_ids": [
      "archive_project",
      "archive_sample",
      "article_material",
      "article_project",
      "archive_submission_chain",
      "supplement_material"
    ],
    "review_status": {
      "technical": "metadata_reconciliation_checked",
      "science": "human_review_pending",
      "rights": "human_review_pending"
    }
  },
  "source_evidence": {
    "archive_project": {
      "path": "docs/assets/mouse-st2-evidence-20261024-r1/sources/PRJDB19137.xml",
      "sha256": "fce88fda9c83253717cc2e876773c9c3040069052ade72ccd14bd43987952fec",
      "selector": "/PROJECT_SET/PROJECT[@accession='PRJDB19137']/TITLE|DESCRIPTION",
      "url": "https://www.ebi.ac.uk/ena/browser/view/PRJDB19137",
      "evidence_role": "author_submitted_archive_metadata"
    },
    "archive_sample": {
      "path": "docs/assets/mouse-st2-evidence-20261024-r1/sources/SAMD00829922.xml",
      "sha256": "6416c81f1c57afbd5a3cedaeab1f02a0051fb681a94a87bcba8b1aa9319f84f3",
      "selector": "/SAMPLE_SET/SAMPLE[@accession='SAMD00829922']/DESCRIPTION; SAMPLE_NAME/TAXON_ID",
      "url": "https://www.ebi.ac.uk/ena/browser/view/SAMD00829922",
      "evidence_role": "author_submitted_archive_metadata"
    },
    "article_material": {
      "path": "docs/assets/mouse-st2-evidence-20261024-r1/sources/raptscore.xml",
      "sha256": "14106c6aea02cdf44e014049e73c0842ca30a26aeb46093469d4928478d2ed2b",
      "selector": ".//sec[@id='SEC2-8']/p[2] (mouse ST2/IL-33R catalogue 1004-MR); p[4] (Fc chimera)",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12802916/",
      "evidence_role": "primary_article_author_report"
    },
    "article_project": {
      "path": "docs/assets/mouse-st2-evidence-20261024-r1/sources/raptscore.xml",
      "sha256": "14106c6aea02cdf44e014049e73c0842ca30a26aeb46093469d4928478d2ed2b",
      "selector": ".//sec[@id='SEC9']/p[1] (Datasets A, B, C -> DRA019577, DRA019609, DRA019610 respectively)",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12802916/",
      "evidence_role": "primary_article_author_report"
    },
    "supplement_material": {
      "path": "docs/assets/mouse-st2-evidence-20261024-r1/sources/supplement-layout.txt",
      "sha256": "bf3df94c004c3599d2f2c7f041284d0c5f7541318b37a0866d7d848d02219e75",
      "selector": "PDF page 2, Supplementary Text 2.2.2 Dataset B; lines 87-95",
      "url": "https://academic.oup.com/nar/article/54/2/gkaf1480/8425320#supplementary-data",
      "evidence_role": "primary_author_supplement"
    },
    "legacy_error": {
      "path": "docs/assets/mouse-st2-evidence-20261024-r1/sources/legacy-uniprot-resolution.tsv",
      "sha256": "1f76c9f37966d32da6b3a9c94ce91ec9a85e1b956fa4b754139e284cebf6d855",
      "selector": "target_id=71; organism_id_used=9606; candidate_accession=Q01638",
      "url": null,
      "evidence_role": "legacy_import_mapping_error"
    },
    "archive_objects": {
      "path": "docs/assets/mouse-st2-evidence-20261024-r1/sources/archive-run-metadata.tsv",
      "sha256": "2fa63302d786f183df71ab7e185df23ce2b434f49b323e431c5964c0b0effde2",
      "selector": "study_accession=PRJDB19137; all 10 source rows",
      "url": "https://www.ebi.ac.uk/ena/portal/api/filereport?accession=PRJDB19137&result=read_run&fields=run_accession,experiment_accession,sample_accession,library_name&format=tsv",
      "evidence_role": "archive_object_association"
    },
    "archive_submission_chain": {
      "path": "docs/assets/mouse-st2-evidence-20261024-r1/sources/DRX598891.xml",
      "sha256": "e295016e46f672e3e7f26fda9107b797084e923aff96565303bb06dcd4d544f0",
      "selector": "/EXPERIMENT_SET/EXPERIMENT[@accession='DRX598891']/STUDY_REF (DRP012519/PRJDB19137); EXPERIMENT_LINKS (ENA-SUBMISSION DRA019609); DESIGN/SAMPLE_DESCRIPTOR (SAMD00829922)",
      "url": "https://www.ebi.ac.uk/ena/browser/view/DRX598891",
      "evidence_role": "archive_submission_project_sample_chain"
    },
    "mouse_reference": {
      "path": "docs/assets/mouse-st2-evidence-20261024-r1/sources/P14719.json",
      "sha256": "7a3f9c9ee6d48c4ac5e9745a5f3acdbdc95d1922832d2023d48aef2c9e7f8356",
      "selector": "primaryAccession; organism.scientificName/taxonId; genes[0].geneName; proteinDescription.alternativeNames",
      "url": "https://www.uniprot.org/uniprotkb/P14719/entry",
      "evidence_role": "external_curated_reference_not_author_accession"
    }
  },
  "field_changes": [
    {
      "field": "source_material_id",
      "before": null,
      "after": "material:PRJDB19137:mouse-st2-1004-mr",
      "basis": [
        "archive_sample",
        "article_material",
        "supplement_material"
      ]
    },
    {
      "field": "normalized_target_species",
      "before": null,
      "after": "Mus musculus (10090)",
      "basis": [
        "archive_sample",
        "article_material"
      ]
    },
    {
      "field": "normalized_target_label",
      "before": "ST2",
      "after": "Recombinant mouse ST2/IL-33R Fc chimera (R&D Systems 1004-MR)",
      "basis": [
        "article_material",
        "supplement_material"
      ]
    },
    {
      "field": "normalized_na_type",
      "before": "DNA",
      "after": "RNA",
      "basis": [
        "archive_project",
        "supplement_material"
      ]
    },
    {
      "field": "normalized_reference_uniprot_id",
      "before": "Q01638",
      "after": "P14719",
      "basis": [
        "mouse_reference"
      ]
    },
    {
      "field": "legacy_target.uniprot_id",
      "before": "Q01638",
      "after": "Q01638",
      "basis": [
        "legacy_error"
      ],
      "note": "Preserved imported value; rejected for material identity and not used as the normalized target reference."
    },
    {
      "field": "registry:0303_positive_link",
      "before": false,
      "after": false,
      "basis": [
        "legacy_error",
        "archive_sample"
      ]
    },
    {
      "field": "resolution_status",
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      "after": "resolved_source_qualified_mouse_material",
      "basis": [
        "archive_sample",
        "article_material",
        "supplement_material"
      ]
    },
    {
      "field": "retained_counts",
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        8,
        51280
      ],
      "after": [
        6410,
        8,
        51280
      ],
      "basis": [],
      "note": "Unchanged existing target-group counts, not newly derived counts."
    }
  ],
  "conclusion": {
    "species_reference_conflict_resolved": true,
    "resolution_level": "source_qualified_mouse_material",
    "historical_677_registry_modified": false,
    "full_construct_identity_resolved": false,
    "source_group_material_link_permitted": true,
    "human_registry_reassignment_permitted": false,
    "still_missing": [
      "assayed_batch_certificate_or_lot",
      "author_reported_exact_protein_construct",
      "exact_old_and_new_run_to_assay_identity"
    ]
  },
  "independent_boundary_checks": {
    "mouse_species_supported_by_two_primary_sources": true,
    "catalogue_number_supported_by_article_and_supplement": true,
    "Fc_chimera_reported_in_primary_article": true,
    "external_reference_not_mislabelled_author_reported": true,
    "no_human_registry_positive_link": true,
    "archive_sample_taxon_not_used_as_protein_species": true,
    "original_sequences_not_processed": true,
    "human_approval_not_fabricated": true
  }
}