{
  "aliases": [
    "NDM-1",
    "NDM1",
    "blaNDM-1",
    "New Delhi metallo-beta-lactamase-1",
    "Metallo-beta-lactamase type 2"
  ],
  "automatic_alias_merging_authorized": false,
  "entity_type": "source_reported_tagged_protein_material",
  "evidence_origin_bundle": {
    "locator_scope": "Artifact names refer to this source evidence package, not the integrated download directory.",
    "manifest_sha256": "e4fd97eac9c2f406d8e16e8f728fdf99cc0d06542bb1b2336874e3de900b4351",
    "name": "ndm1-registration-evidence-20261024-r1"
  },
  "field_proposals": [
    {
      "basis": "Primary article material name, explicit project linkage, and 677-row equivalence audit.",
      "field": "registry_relation",
      "old": "entry_absent",
      "proposed": "source_named_material_registration_proposal"
    },
    {
      "basis": "Author wording derived from E. coli is ambiguous; Klebsiella belongs to the external reference entry.",
      "field": "assayed_protein_source_organism",
      "missing_reason": "not_reported_or_ambiguous",
      "old_legacy_target_value": "Klebsiella pneumoniae",
      "proposed": null
    },
    {
      "basis": "No explicit expression-host statement for the purchased NDM-1 material was identified.",
      "field": "reported_expression_host",
      "missing_reason": "not_reported_or_ambiguous",
      "proposed": null
    },
    {
      "basis": "Official reference metadata plus unapproved free-text resolution provenance.",
      "field": "reference_accession_relation",
      "old_legacy_value": "C7C422 without qualification",
      "proposed": "C7C422 external reference candidate; not author-reported or construct-verified"
    }
  ],
  "identity_aliases": [
    "NDM-1",
    "NDM1",
    "blaNDM-1",
    "New Delhi metallo-beta-lactamase-1"
  ],
  "integration_constraints": {
    "canonical_registry_mutated": false,
    "historical_677_registry_preserved": true,
    "public_site_mutated": false
  },
  "material": {
    "accession_scan": {
      "matches_in_article_xml": 0,
      "term": "C7C422"
    },
    "assayed_material_accession_reported": null,
    "assayed_protein_source_organism": null,
    "data_availability_locator": "Data availability > SRA accession statement",
    "data_availability_project": "PRJNA830749",
    "doi": "10.1038/s41598-022-12062-2",
    "library_type_locator": "Abstract and Methods > Nucleic acid preparation",
    "library_type_reported": "DNA",
    "material_locator": "Methods > Target preparation > first paragraph, first sentence",
    "material_name": "N-terminally hexa-HIS-tagged NDM-1",
    "organism_missing_reason": "not_reported_or_ambiguous: derived from E. coli does not distinguish natural source organism from expression or preparation provenance",
    "pmcid": "PMC9106695",
    "reported_expression_host": null,
    "source_capture_retrieved_at": "2026-09-16T01:39:22.597263+00:00",
    "source_capture_sha256": "8e0f5adc46b96a98e8f6accb8510391233c2482ef06e82f90d580ef29df8c375",
    "source_reported_material_provenance_text": "NDM-1 (derived from E. coli)",
    "source_url": "https://www.nature.com/articles/s41598-022-12062-2",
    "supplier_reported": "Hölzel Diagnostica Handels GmbH"
  },
  "proposal_id": "ndm1-registration-20261024-r1",
  "proposed_name": "NDM-1",
  "proposed_registry_id": "registry:0679",
  "reference": {
    "accession": "C7C422",
    "author_reported_accession": false,
    "database": "UniProtKB",
    "entry_name": "BLAN1_KLEPN",
    "exact_assayed_construct_identity_verified": false,
    "legacy_resolution": "free_text_automatic_candidate_unapproved",
    "reference_organism": "Klebsiella pneumoniae",
    "reference_taxid": 573,
    "relation_to_assayed_material": "external_name_correspondence_not_exact_construct_identity"
  },
  "reference_display_names": [
    "Metallo-beta-lactamase type 2"
  ],
  "remaining_gaps": [
    "Exact purchased construct accession or supplier lot/catalogue identity is not reported in the reviewed material paragraph.",
    "Natural protein source species and expression/preparation host are not distinguished by the author phrase derived from E. coli.",
    "Exact assayed-construct equivalence to C7C422 has not been established."
  ],
  "review_status": {
    "rights": "human_review_pending",
    "science": "human_review_pending",
    "technical_metadata_evidence": "checked"
  },
  "schema": "panapta-source-qualified-registration-proposal/v1",
  "scope": "identity_and_source_metadata_only",
  "sequence_content_included": false,
  "source_bundle_artifacts": [
    "article-identity-metadata.json",
    "uniprot-identity-only.tsv",
    "uniprot-identity-receipt.json",
    "archive-identity-metadata.json",
    "equivalence-audit.json",
    "legacy-reference-resolution.json",
    "old-target-metadata.json"
  ],
  "source_target_association": {
    "candidate_assignment_to_registered_reference_approved": false,
    "count_scope": "existing retained source-group counts; no recounted or newly processed sequence data",
    "doi": "10.1038/s41598-022-12062-2",
    "material_identity_fully_adjudicated": false,
    "project": "PRJNA830749",
    "relation": "source_named_assayed_protein_material",
    "retained_candidate_records": 10000,
    "retained_round_records": 4,
    "sequence_round_observations": 40000,
    "source_name_supported": true,
    "target_id": 2633
  },
  "status": "source_qualified_registration_proposal_ready"
}