Affinity records
Curated Kd, Ki, IC50, EC50 and other binding-related measurements from public sources. Measurement types remain explicit and should not be interpreted as interchangeable endpoints.
Total
2,681
With positive, finite nM value
2,565
AptamerBase
1,171
PDB
56
Ribocentre
360
UTexas
1,094
| Target | Aptamer | NA | Type | Relation | Reported value | Normalized (nM) | Source | Method | Year | PubMed |
|---|---|---|---|---|---|---|---|---|---|---|
| Arsenate | 20000526-arsenic-Ma-1 | DNA | Kd | = | 6.15e-16 | 6.15e-07 | AptamerBase | — | — | 20000526 ↗ |
| Arsenite | 20000526-arsenic-Ma-1 | DNA | Kd | = | 1.32e-15 | 1.32e-06 | AptamerBase | — | — | 20000526 ↗ |
| Keratinocyte growth factor (hKGF), Human | — | RNA | Kd | = | 0.001 | 0.001 | UTexas | — | — | — |
| Liver X receptors beta (LXRbeta, LXRβ) | — | DNA | Kd | = | 0.00111 | 0.00111 | UTexas | — | — | — |
| Polyhistidine-tag | 19520059-His-tag-1 | RNA | Kd | = | 3.78e-12 | 0.00378 | AptamerBase | — | — | 19520059 ↗ |
| Polyhistidine-tag | 19520059-His-tag-Ma-2 | RNA | Kd | = | 3.78e-12 | 0.00378 | AptamerBase | — | — | 19520059 ↗ |
| Polyhistidine-tag | 19520059-His-tag-Ma-1 | RNA | Kd | = | 3.78e-12 | 0.00378 | AptamerBase | — | — | 19520059 ↗ |
| Autonomously replicating sequence‐binding factor 1 (ABF1) protein | — | DNA | Kd | = | 0.006 | 0.006 | UTexas | — | — | — |
| C-reactive protein (CRP). Human | — | DNA | Kd | = | 0.0062 | 0.0062 | UTexas | — | — | — |
| Group A streptococcus (GAS) serotype M4 | — | DNA | Kd | = | 0.00747 | 0.00747 | UTexas | — | — | — |
| Liver X receptors beta (LXRbeta, LXRβ) | — | DNA | Kd | = | 0.0079 | 0.0079 | UTexas | — | — | — |
| Liver X receptors beta (LXRbeta, LXRβ) | — | DNA | Kd | = | 0.008 | 0.008 | UTexas | — | — | — |
| Group A streptococcus (GAS) serotype M3 | — | DNA | Kd | = | 0.00825 | 0.00825 | UTexas | — | — | — |
| DNA polymerase (Taq pol), Thermus acquaticus | — | DNA | Kd | = | 0.009 | 0.009 | UTexas | — | — | — |
| DNA polymerase (Taq pol), Thermus acquaticus | — | DNA | Kd | = | 0.01 | 0.01 | UTexas | — | — | — |
| Rabbit immunoglobulin G (IgG) | 18252191-Rabbit IgG-2 | RNA | Kd | = | 1.5e-11 | 0.015 | AptamerBase | — | — | 18252191 ↗ |
| G-protein-coupled cholecystokinin B receptor (CCKBR) | — | DNA | Kd | = | 0.0155 | 0.0155 | UTexas | — | — | — |
| Basic fibroblast growth factor (bFGF(155)), Human | — | DNA | Kd | = | 0.016 | 0.016 | UTexas | — | — | — |
| Liver X receptors alpha (LXRalpha, LXRα) | — | DNA | Kd | = | 0.0184 | 0.0184 | UTexas | — | — | — |
| Liver X receptors alpha (LXRalpha, LXRα) | — | DNA | Kd | = | 0.019 | 0.019 | UTexas | — | — | — |
| Liver X receptors alpha (LXRalpha, LXRα) | — | DNA | Kd | = | 0.0242 | 0.0242 | UTexas | — | — | — |
| Toll-like receptor 2 | 19406842-TLR2-4 | DNA | Kd | = | 2.8e-11 | 0.028 | AptamerBase | — | — | 19406842 ↗ |
| Keratinocyte growth factor (hKGF), Human | — | RNA | Kd | = | 0.03 | 0.03 | UTexas | — | — | — |
| Variant surface glycoprotein 221 (sVSG 221) | — | RNA | Kd | = | 0.03 | 0.03 | UTexas | — | — | — |
| Prostate specific membrane antigen (PSMA) positive LNCaP cells | — | DNA | Kd | = | 0.03378 | 0.03378 | UTexas | — | — | — |
| Thermus aquaticus DNA polymerase (Taq pol) | — | DNA | Kd | = | 0.04 | 0.04 | UTexas | — | — | — |
| DNA polymerase (Taq pol), Thermus acquaticus | — | DNA | Kd | = | 0.04 | 0.04 | UTexas | — | — | — |
| DNA polymerase (Tth pol), Thermus thermophilus (Tth) | — | DNA | Kd | = | 0.04 | 0.04 | UTexas | — | — | — |
| DNA polymerase (Taq pol), Thermus acquaticus | — | DNA | Kd | = | 0.047 | 0.047 | UTexas | — | — | — |
| Interleukin-17A (IL‐17A) | — | RNA | Kd | = | 0.0485 | 0.0485 | UTexas | — | — | — |
| human interleukin 17A | 20967861-IL17A-1 | DNA | Kd | = | 4.85e-11 | 0.0485 | AptamerBase | — | — | 20967861 ↗ |
| Proinflammatory cytokine interleukin-17A (IL-17A) | Proinflammatory cytokine interleukin-17A (IL-17A)_Apt21‐2 | RNA | Kd | = | Kd: 48.5 pM | 0.0485 | Ribocentre | — | 2011 | 20967861 ↗ |
| Proinflammatory cytokine interleukin-17A (IL-17A) | Proinflammatory cytokine interleukin-17A (IL-17A)_Apt21-2 aptamer(truncation) | RNA | Kd | = | Kd: 48.5 pM | 0.0485 | Ribocentre | — | 2011 | 20967861 ↗ |
| Vascular Endothelial Growth Factor (VEGF) | Vascular Endothelial Growth Factor (VEGF)_t44-OMe | RNA | Kd | = | Kd: 49±6 pM | 0.049 | Ribocentre | — | 1998 | 9685413 ↗ |
| Digoxin | — | DNA | Kd | = | 0.05 | 0.05 | UTexas | — | — | — |
| Keratinocyte growth factor (hKGF), Human | — | RNA | Kd | = | 0.05 | 0.05 | UTexas | — | — | — |
| Prostate specific membrane antigen (PSMA) positive LNCaP cells | — | DNA | Kd | = | 0.05749 | 0.05749 | UTexas | — | — | — |
| Angiopoietin-2 (Ang2), Human | — | DNA | Kd | = | 0.062 | 0.062 | UTexas | — | — | — |
| Keratinocyte growth factor (hKGF), Human | — | RNA | Kd | = | 0.07 | 0.07 | UTexas | — | — | — |
| Keratinocyte growth factor (hKGF), Human | — | RNA | Kd | = | 0.07 | 0.07 | UTexas | — | — | — |
| Toll-like receptor 2 | 19406842-TLR2-7 | DNA | Kd | = | 7.3e-11 | 0.073 | AptamerBase | — | — | 19406842 ↗ |
| Influenza virus subtype H1N1 | — | DNA | Kd | = | 0.082 | 0.082 | UTexas | — | — | — |
| Sialyl Lewis X (sLeX)-expressing HL60 cells | — | RNA | Kd | = | 0.085 | 0.085 | UTexas | — | — | — |
| Sialyl-LewisX | 11178986-SialylLewisX-1 | RNA | Kd | = | 8.5e-11 | 0.085 | AptamerBase | — | — | 11178986 ↗ |
| Sialyl Lewis X (sLeX) | Sialyl Lewis X (sLeX)_Clone 5 | RNA | Kd | = | Kd: 0.085 nM and 3.3 nM via SPR | 0.085 | Ribocentre | — | 2001 | 11178986 ↗ |
| Influenza virus subtype H3N2 | — | DNA | Kd | = | 0.088 | 0.088 | UTexas | — | — | — |
| C-Met receptor | — | DNA | Kd | = | 0.09 | 0.09 | UTexas | — | — | — |
| Platelet-derived growth factor (PDGF)-BB | — | DNA | Kd | = | 0.093 | 0.093 | UTexas | — | — | — |
| Platelet-derived growth factor receptor beta | 8916928-PDGF-BB-Ma-1 | DNA | Kd | = | 9.3e-11 | 0.093 | AptamerBase | — | — | 8916928 ↗ |
| Platelet-derived growth factor (PDGF)-AB | — | DNA | Kd | = | 0.094 | 0.094 | UTexas | — | — | — |
| Platelet-derived growth factor | 8916928-PDGF-AB-Ma-1 | DNA | Kd | = | 9.4e-11 | 0.094 | AptamerBase | — | — | 8916928;8926928 ↗ |
| Toll-like receptor 2 | 19406842-TLR2-5 | DNA | Kd | = | 9.7e-11 | 0.097 | AptamerBase | — | — | 19406842 ↗ |
| C-Met receptor | — | DNA | Kd | = | 0.1 | 0.1 | UTexas | — | — | — |
| Mitochondria | — | RNA | Kd | = | 0.1 | 0.1 | UTexas | — | — | — |
| Mitochondria | Mitochondria_C32 | RNA | Kd | = | Kd: 0.1 nM | 0.1 | Ribocentre | — | 2002 | 12024047 ↗ |
| Fluoroquinolones | — | DNA | Kd | = | 0.11 | 0.11 | UTexas | — | — | — |
| Hemagglutinin (HA) of highly pathogenic avian influenza (HPAI H5N1) | — | RNA | Kd | = | 0.11 | 0.11 | UTexas | — | — | — |
| Hemagglutinin influenza virus (HA influenza virus) | — | RNA | Kd | = | 0.115 | 0.115 | UTexas | — | — | — |
| HA of H3N2 | Hemagglutinin (HA)_clone B | RNA | Kd | = | Kd: 115±23 pM | 0.115 | Ribocentre | — | 2005 | 15913532 ↗ |
| Keratinocyte growth factor (hKGF), Human | — | RNA | Kd | = | 0.12 | 0.12 | UTexas | — | — | — |
| hnps_PLA2 | 9526554-hnps_PLA2-8 | RNA | Kd | = | 1.2e-10 | 0.12 | AptamerBase | — | — | 9526554 ↗ |
| HIV-1 Tat Protein | 10886365-HIV1Tat-1 | RNA | Kd | = | 1.2e-10 | 0.12 | AptamerBase | — | — | 10886365 ↗ |
| HIV Tat peptides | HIV Tat peptides_RNA Tat aptamer | RNA | Kd | = | Kd: 120±13 pM | 0.12 | Ribocentre | — | 2000 | — |
| Platelet-derived growth factor (PDGF)-BB | — | DNA | Kd | = | 0.127 | 0.127 | UTexas | — | — | — |
| Platelet-derived growth factor receptor beta | 8916928-PDGF-BB-Ma-2 | DNA | Kd | = | 1.27e-10 | 0.127 | AptamerBase | — | — | 8916928 ↗ |
| Platelet-derived growth factor (PDGF)-BB | — | DNA | Kd | = | 0.129 | 0.129 | UTexas | — | — | — |
| Platelet-derived growth factor receptor beta | 8916928-PDGF-BB-Ma-3 | DNA | Kd | = | 1.29e-10 | 0.129 | AptamerBase | — | — | 8916928 ↗ |
| Glutaminyl-tRNA synthetase | 10881199-GlnRS-2 | RNA | Kd | = | 1.3e-10 | 0.13 | AptamerBase | — | — | 10881199 ↗ |
| Escherichia coli (E. coli) core bacterial RNA polymerase (RNAP) | — | DNA | Kd | = | 0.13 | 0.13 | UTexas | — | — | — |
| Basic fibroblast growth factor (bFGF) | — | RNA | Kd | = | 0.13 | 0.13 | UTexas | — | — | — |
| Mucin 1 (MUC1) | — | DNA | Kd | = | 0.135 | 0.135 | UTexas | — | — | — |
| MUC1 peptide APDTRPAPG | 17033199-MUC1 peptide APDTRPAPG-2 | DNA | Kd | = | 1.35e-10 | 0.135 | AptamerBase | — | — | 17033199 ↗ |
| Platelet-derived growth factor | 8916928-PDGF-AB-Ma-3 | DNA | Kd | = | 1.38e-10 | 0.138 | AptamerBase | — | — | 8916928;8926928 ↗ |
| Platelet-derived growth factor (PDGF)-AB | — | DNA | Kd | = | 0.138 | 0.138 | UTexas | — | — | — |
| Influenza virus subtype H3N2 | — | DNA | Kd | = | 0.14 | 0.14 | UTexas | — | — | — |
| Vascular Endothelial Growth Factor (VEGF) | — | RNA | Kd | = | 0.14 | 0.14 | UTexas | — | — | — |
| Vascular pemeability factor/vascular endothelial growth factor (VPF/VEGF) | — | RNA | Kd | = | 0.14 | 0.14 | UTexas | — | — | — |
| hnps_PLA2 | 9526554-hnps_PLA2-4 | RNA | Kd | = | 1.4e-10 | 0.14 | AptamerBase | — | — | 9526554 ↗ |
| Vascular Endothelial Growth Factor (VEGF) | Vascular Endothelial Growth Factor (VEGF)_NX-213 aptamer | RNA | Kd | = | Kd: 0.14±0.01 nM | 0.14 | Ribocentre | — | 1995 | 9383475 ↗ |
| Platelet-derived growth factor (PDGF)-AB | — | DNA | Kd | = | 0.147 | 0.147 | UTexas | — | — | — |
| Platelet-derived growth factor | 8916928-PDGF-AB-Ma-2 | DNA | Kd | = | 1.47e-10 | 0.147 | AptamerBase | — | — | 8916928;8926928 ↗ |
| Variant surface glycoprotein 221 (sVSG 221) | — | RNA | Kd | = | 0.16 | 0.16 | UTexas | — | — | — |
| Hemagglutinin (HA) of highly pathogenic avian influenza (HPAI H5N1) | — | RNA | Kd | = | 0.17 | 0.17 | UTexas | — | — | — |
| APCexosite | 19389630-APCexosite-Ma-5 | DNA | Kd | = | 1.7e-10 | 0.17 | AptamerBase | — | — | 19389630 ↗ |
| Hemagglutinin (HA) of H5N1 and H7N7 | Hemagglutinin (HA) of H5N1 and H7N7_8-3 | RNA | Kd | = | Kd: 170 pM | 0.17 | Ribocentre | — | 2014 | 24374323 ↗ |
| Serine protease inhibitor plasminogen activator inhibitor-1 (PAI-1) | — | RNA | Kd | = | 0.177 | 0.177 | UTexas | — | — | — |
| Plasminogen activator inhibitor-1 | 19284310-PAI1-2 | DNA | Kd | = | 1.77e-10 | 0.177 | AptamerBase | — | — | 19284310 ↗ |
| PAI1 | 19284310-PAI1-2 | DNA | Kd | = | 1.77e-10 | 0.177 | AptamerBase | — | — | 19284310 ↗ |
| Serine protease inhibitor plasminogen activator inhibitor-1 (PAI-1) | Serine protease inhibitor plasminogen activator inhibitor-1 (PAI-1)_WT-15 | RNA | Kd | = | Kd: 177 pM | 0.177 | Ribocentre | — | 2009 | 19284310 ↗ |
| Human immunodeficiency virus reverse transcriptase (HIVRT) | — | DNA | Kd | = | 0.18 | 0.18 | UTexas | — | — | — |
| Monocyte chemoattractant protein‐1 (MCP‐1) | — | RNA | Kd | = | 0.18 | 0.18 | UTexas | — | — | — |
| hnps_PLA2 | 9526554-hnps_PLA2-7 | RNA | Kd | = | 1.8e-10 | 0.18 | AptamerBase | — | — | 9526554 ↗ |
| Hemagglutinin influenza virus (HA influenza virus) | — | RNA | Kd | = | 0.188 | 0.188 | UTexas | — | — | — |
| Haemagglutinin (HA) region of the target strain A/Panama/2007/1999(H3N2) | — | RNA | Kd | = | 0.188 | 0.188 | UTexas | — | — | — |
| human influenza A/Panama/2007/1999(H3N2) virus | 16476969-influenza A/Panama-1 | RNA | Kd | = | 1.88e-10 | 0.188 | AptamerBase | — | — | 16476969 ↗ |
| HA of H3N2 | Hemagglutinin (HA)_clone A (wild type) | RNA | Kd | = | Kd: 188±36 pM | 0.188 | Ribocentre | — | 2005 | 15913532 ↗ |
| Haemagglutinin (HA) region of the target strain A/Panama/2007/1999(H3N2) | Haemagglutinin (HA) region of the target strain A/Panama/2007/1999(H3N2)_P30-10-16 | RNA | Kd | = | Kd: 188 pM | 0.188 | Ribocentre | — | 2006 | 16476969 ↗ |
| Basic fibroblast growth factor (bFGF) | — | RNA | Kd | = | 0.19 | 0.19 | UTexas | — | — | — |
| Basic fibroblast growth factor (bFGF) | — | RNA | Kd | = | 0.19 | 0.19 | UTexas | — | — | — |
| Vascular Endothelial Growth Factor (VEGF) | — | RNA | Kd | = | 0.19 | 0.19 | UTexas | — | — | — |