SNCA
registry:0430 · P37840
Experimental material and evidence scope
- Experimental material
- Source-reported F-type alpha-synuclein fibrils
- Material type
- Source-named material
- Material identity
- Material qualified by source
- Source support
- Supported or qualified
- Relationship to the registered name
- Existing source association
- Research purpose
- Aptamer selection
Both S1 and S2 selected against F-type alpha-synuclein fibrils; they are source-reported selection branches, not different proteins. Two existing retained-candidate groups and a sequence-free derived evidence case are public. Complete deposited-read query/download routes are not publicly released. P37840 remains a registry reference, not a verified experimental construct identity.
Applied source-classification correction
Target search and filters use protein (F-type fibrils) / RNA library (2′-fluoro pyrimidines). Original imported cell / DNA classifications are preserved for traceability.
Source-library classification does not establish each sequence’s complete chemistry. Stored sequences, species, reference accessions and docking eligibility are unchanged.
Download classification correctionsClassification evidence JSON
Query and download access
Selection-to-evidence case Public access checked
sequence_free_derived_source_correspondence
Checked: 2026-10-23T08:20:47.189031+00:00 · GET public derived-case page; no nucleotide strings
Sequence-free case metadata Public access checked
sequence_free_derived_source_correspondence
Checked: 2026-10-23T08:20:33.230998+00:00 · GET public metadata; no sequence query fetched
Case version manifest Public access checked
sequence_free_derived_source_correspondence
Checked: 2026-10-23T08:20:34.151238+00:00 · GET public metadata; no sequence query fetched
PRJEB70964 at ENA Public access checked
Source context
Checked: 2026-10-23T08:20:48.342569+00:00 · HEAD external archive landing page; no archive read files fetched
Show remaining 13 data entries
README.txt Public access checked
sequence_free_derived_source_correspondence
Checked: 2026-10-23T08:20:38.600703+00:00 · GET sequence-free derived case artifact; exact manifest bytes and SHA-256 checked
archive-rounds.tsv Public access checked
sequence_free_derived_source_correspondence
Checked: 2026-10-23T08:20:39.493818+00:00 · GET sequence-free derived case artifact; exact manifest bytes and SHA-256 checked
case.json Public access checked
sequence_free_derived_source_correspondence
Checked: 2026-10-23T08:20:40.824609+00:00 · GET sequence-free derived case artifact; exact manifest bytes and SHA-256 checked
construct-links.tsv Public access checked
sequence_free_derived_source_correspondence
Checked: 2026-10-23T08:20:41.652291+00:00 · GET sequence-free derived case artifact; exact manifest bytes and SHA-256 checked
published-percentage-crosscheck.tsv Public access checked
sequence_free_derived_source_correspondence
Checked: 2026-10-23T08:20:42.599105+00:00 · GET sequence-free derived case artifact; exact manifest bytes and SHA-256 checked
read-frequency-source-data.tsv Public access checked
sequence_free_derived_source_correspondence
Checked: 2026-10-23T08:20:44.175375+00:00 · GET sequence-free derived case artifact; exact manifest bytes and SHA-256 checked
reported-kd-source-data.tsv Public access checked
sequence_free_derived_source_correspondence
Checked: 2026-10-23T08:20:45.138179+00:00 · GET sequence-free derived case artifact; exact manifest bytes and SHA-256 checked
alpha-synuclein_S1 Linked; not live-checked
Retained source–target group
alpha-synuclein_S1 Linked; not live-checked
Retained source–target group
S1 retained round records Public access checked
Retained source–target group
Checked: 2026-10-23T08:20:36.002828+00:00 · GET public metadata; no sequence query fetched
alpha-synuclein_S2 Linked; not live-checked
Retained source–target group
alpha-synuclein_S2 Linked; not live-checked
Retained source–target group
S2 retained round records Public access checked
Retained source–target group
Checked: 2026-10-23T08:20:37.703354+00:00 · GET public metadata; no sequence query fetched
Counts and their scope
17 retained branch-round records; not all 27 archived objects. A retained last-round flag is not the experiment endpoint.
| Measure | Count | Scope or reason unavailable |
|---|---|---|
| Independent molecular targets | Undetermined | this registration Experimental identity unresolved |
| Processed source sequence rows | 200,400,656 sequence–source rows | historical processed source labels; not public unique sequences |
| Retained candidate records | 20,000 candidate records | sum of distinct linked source-target groups; not globally unique sequences |
| Round records | 17 round records | sum of distinct linked source-target groups; not globally unique sequences |
| Sequence–round observations | 170,000 sequence–round observations | sum of distinct linked source-target groups; not globally unique sequences |
| Target-specific read records | Undetermined | experiment material matched to this registration No target-specific count established |
Sources and supporting relationships
Deposited count metadata · PRJEB70964 · PRJEB70964
Historically processed complete project counts. Internal availability does not imply public full-archive query or download.
Public source-linked case · PRJEB70964 · PRJEB70964
Published source-linked case: selected construct-to-archive correspondence and reported measurements; not complete archive reads or retained-candidate counts.
Source-qualified selection branch · legacy-target:2614 · PRJEB70964
Same project and source-reported alpha-synuclein selection branch; not an accession-exact match or verified individual molecule.
Source-qualified selection branch · legacy-target:2615 · PRJEB70964
Same project and source-reported alpha-synuclein selection branch; not an accession-exact match or verified individual molecule.
Remaining evidence gaps
- S1/S2 source-name and project links are established; P37840 and the exact experimental construct identity are not independently verified.
- Complete deposited-read queries/downloads belong to historical internal processing. Current public entries provide retained subsets and sequence-free derived case tables.
- Source-level target and library classes are standardized to protein fibrils and RNA. Stored candidate labels and sequences are preserved; complete per-candidate chemistry and exact assayed construct identity remain unverified.